Luck found Coby Fleener for a 32-yard score, T.Y Hilton for a 31-yard score, Reggie Wayne for a 40-yards score, and a 2-yard score to Dwayne Allen. It was the 8th time this season that the Colts' QB threw for more than 300 yards, and the 17th time in his career.
He finished 25/46 with no interceptions, as Indianapolis heads in to a bye week with a 2-game lead over the Houston Texans in the AFC South.
Wayne broke down in tears during the national anthem, and then surpassed James Lofton for career yards receiving with 14,070.
Adam Vinatieri finished 4/4 in field goals on the night, from 48, 31, 48, and 43 yards. Vinatieri is now perfect in 20 attempts this season.
The Giants fell to 3-5 on the season, losing their 3rd straight game. The were lead by receiver Odell Beckham Jr., who had 8 catches for 156 yards. Eli Manning was 27/52 for 359 yards and 2 touchdowns. Manning did not throw an interception, but did have 1 fumble loss, which was returned 28 yards.
New York had a turnover for the 24th consecutive game, which is the longest current streak in the NFL. They were held to just 143 yards in the 1st half, and continue their streaky start to the season. They have a tough test this Sunday, looking to end their losing streak, as they visit the Seattle Seahawks.