The issue stems back to January 2015 in the Patriots' blowout win over the Colts in the AFC Divisional game. The NFL Player's Association expressed their disappointment in the decision not to have a rehearing. They are still adamant that "there were clear violations of our collective bargaining agreement."
Brady's last hope is to appeal to the U.S. Supreme Court. Sources say that the denial was expected from the appeals court, and the decision for the next step has not officially been made.
Despite the announcement, the Patriots remain the favorites to win the Super Bowl at 6-1, and have a total win expectancy of 10.5. New England opens the season on September 11th at Arizona. They will also face the Dolphins, Texans and Bills in the first four weeks of the year, which could be started by Jimmy Garoppolo.
Brady, who recently signed a two-year contract extension, would make his season debut in Week 5 against the Cleveland Browns if the suspension stands.